Lansoprazole is a “proton pump inhibitor” drug that blocks production of
stomach acid. Lansoprazole is used to treat diseases in which stomach acid causes damage,
including stomach and duodenal ulcers,
esophagitis, and Zollinger-Ellison syndrome.
Helpful Products
Try these helpful products which may be beneficial if taken with this medicine
Beta-carotene
To avoid possible depletion of beta-carotene, eat more dark green and orange-yellow
vegetables and consider supplementing with 25,000 IU per day
Vitamin B12 and folic acid
To avoid depleting these nutrients, which might lead to anemia and high homocysteine blood
levels, take 1,000 mcg of vitamin B12 and 400 mcg of folate daily
Cranberry juice
Drinking cranberry juice may help prevent vitamin B12 deficiency as it increases the
body's ability to absorb this nutrient from food in people taking this medicine
These recommendations are not comprehensive and are not intended to
replace the advice of your doctor or pharmacist. Continue reading the full article for more
information on interactions with vitamins, herbs, and foods.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
May Be Beneficial:Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them.
Beta-carotene*
Folic acid
Vitamin B12* (dietary, not supplemental B12)
May Be Beneficial:Supportive
interaction—Taking these supplements may support or otherwise help your medication
work better.
Cranberry*
Side effect reduction/prevention
None known
Reduced drug
absorption/bioavailability
None known
Adverse interaction
None known
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Interactions with Dietary Supplements
Beta-carotene Omeprazole, a drug closely related to
lansoprazole, taken for seven days led to a near-total loss of stomach acid in healthy people
and interfered with the absorption of a single administration of 120 mg of
beta-carotene.1 It is unknown whether repeated administration of beta-carotene
would overcome this problem or if absorption of carotenoids from food would be impaired.
Persons taking omeprazole and related acid-blocking drugs for long periods may want to have
carotenoid blood levels checked, eat plenty of
fruits and vegetables, and consider
supplementing with carotenoids.
Folic
acid
Folic acid is needed by the body to utilize
vitamin B12. Antacids, including lansoprazole, inhibit folic acid absorption.2
People taking antacids are advised to supplement with folic acid.
Vitamin
B12
Omeprazole, a drug closely related to lansoprazole, has interfered with the absorption of
vitamin B12 from food (though not supplements) in some,34 but not all,
studies.56 This interaction has not yet been reported with
lansoprazole. However, a fall in vitamin B12 status may result from decreased stomach acid
caused by acid blocking drugs, including lansoprazole.7
Interactions with Herbs
Cranberry(Vaccinium macrocarpon) Omeprazole was shown to reduce protein-bound
vitamin B12 absorption and cranberry juice was
shown to increase protein-bound vitamin B12 absorption in eight people treated with omeprazole
(a drug closely related to lansoprazole).8 While this effect has not been studied
with lansoprazole, people taking lansoprazole may choose to drink cranberry juice or other
acidic liquids with vitamin B12-containing foods. Unlike vitamin B12 found in food, vitamin
B12 found in supplements is not bound to peptides (pieces of protein). The absorption of B12
supplements therefore does not require acid and is unlikely to be improved by drinking
cranberry juice.
Interactions with Foods and Other Compounds
Food
The initial dose of lansoprazole should be taken 30 minutes before a meal.9
Subsequent doses are equally effective taken with or without food but should be taken at the
same time every day.10 Capsules and granule contents should not be chewed or
crushed. However, lansoprazole capsules may be opened, the granule contents sprinkled on one
tablespoon of applesauce, then immediately swallowed.
References (To view, roll mouse over the "References" heading; to hide, click on the heading)
1. Tang G, Serfaty-Lacronsniere C, Camilo ME, Russell RM. Gastric acidity
influences the blood response to a beta-carotene dose in humans. Am J Clin Nutr
1996;64:622–6.
2. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2
receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med
1988;112:458–63.
3. Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes
malabsorption of cyanocobalamin (Vitamin B12). Ann Intern Med
1994;120:211–5.
4. Termanini B, Gibril F, Sutliff VE, et al. Effect of long-term gastric
acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison
syndrome. Am J Med 1998;104:422–30.
5. Koop H, Bachem MG. Serum iron, ferritin, and vitamin B12 during
prolonged omeprazole therapy. J Clin Gastroenterol 1992;14:288–92.
6. Schenk BE, Festen HP, Kuipers EJ, et al. Effect of short-and long-term
treatment with omeprazole on the absorption and serum levels of cobalamin. Aliment
Pharmacol Ther 1996;10:541–5.
7. Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due
to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. J
Am Coll Nutr 1994;13:584–91.
8. Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due
to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. J
Am Coll Nutr 1994;13:584–91.
9. Brummer RJ, Geerling BJ, Stockbrugger RW. Initial and chronic gastric
acid inhibition by lansoprazole and omeprazole in relation to meal administration. Dig Dis
Sci 1997;42:2132–7.
10. Threlkeld DS, ed. Gastrointestinal Drugs, Proton Pump Inhibitors. In
Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Apr
1998, 305r.
The information presented in Aisle7 is for informational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience,
or traditional usage as cited in each article. The results reported may not necessarily occur
in all individuals. For many of the conditions discussed, treatment with prescription or over
the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist
for any health problem and before using any supplements or before making any changes in
prescribed medications.
